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KMID : 0371420221030010019
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Annals of Surgical Treatment and Research
2022 Volume.103 No. 1 p.19 ~ p.31
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Postoperative quality of life after gastrectomy in gastric cancer patients: a prospective longitudinal observation study
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Wang Chao-Jie
Suh Yun-Suhk
Lee Hyuk-Joon
Park Ji-Hyeon
Park Shin-Hoo
Choi Jong-Ho
Alzahrani Fadhel
Alzahrani Khalid
Kong Seong-Ho
Park Do-Joong
Cao Hui
Yang Han-Kwang
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Abstract
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Purpose: The European Organization for Research and Treatment of Cancer quality of life (QOL) questionnaires (QLQ-C30, QLQ-OG25, and QLQ-STO22) are widely used for the assessment of gastric cancer patients. This study aimed to use these questionnaires to evaluate QOL in postgastrectomy patients.
Methods: We prospectively evaluated 106 patients with distal gastrectomy (DG), 57 with pylorus-preserving gastrectomy (PPG), and 117 with total gastrectomy (TG). Body weight and QOL questionnaires were evaluated preoperatively and postoperatively (at 3 weeks, and 3, 6, and 12 months).
Results: TG patients had significantly more weight loss than DG/PPG patients. Compared with DG, patients after PPG had less dyspnea (P = 0.008) and trouble with coughing (P = 0.049), but more severe symptoms of insomnia (P = 0.037) and reflux (P = 0.030) at postoperative 12 months. Compared with DG/PPG, TG was associated with worse body image, dysphagia, eating, and taste in both OG25 and STO22. Moreover, OG25 revealed worse QOL in the TG group with respect to odynophagia, eating with others, choked when swallowing, trouble talking, and weight loss. The QOL of patients who received chemotherapy was worse than those in the chemo-free group in both physical functioning and symptoms such as nausea/vomiting, appetite loss, and trouble with taste; however, these side effects would soon disappear after finishing chemotherapy.
Conclusion: PPG was similar to DG in terms of postoperative QOL and maintaining body weight, while TG was always inferior to both DG and PPG. Adjuvant chemotherapy can affect both body weight and QOL despite being reversible.
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KEYWORD
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Chemotherapy, European Organization for Research and Treatment of Cancer quality of life, Gastrectomy, Quality of life, Weight loss
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